The Oxford-RCGP RSC has a current membership of over 1900 general practices in England covering almost 18 million patients who are broadly representative of the English general population. The emergent COVID-19 pandemic has seen a rapid increase in the number of new practices joining the network to support the national surveillance program. The Oxford-RCGP RSC team transforms routine clinical data from individual patient records at practice level into an accessible repository of data for health research. Data is transformed to series of themed datasets readily available research. These datasets include standard RSC population configuration (based on age band, ethnicity, index of multiple deprivation, and rurality), clinical case definitions (generally ontological), covariates, and outcomes. These are benchmarked to ONS standard populations to enable rapid comparisons between the study and national populations.