The association between serum sodium concentration, hypertension and primary cardiovascular events: a retrospective cohort study
Cole NI., Suckling RJ., Swift PA., He FJ., MacGregor GA., Hinton W., van Vlymen J., Hayward N., Jones S., de Lusignan S.
© 2018, Springer Nature Limited. The mechanisms underlying the adverse cardiovascular effects of increased salt intake are incompletely understood, but parallel increases in serum sodium concentration may be of importance. The aim of this retrospective cohort study was to investigate the relationship between serum sodium, hypertension and incident cardiovascular disease (CVD). Routinely collected primary care data from the Royal College of General Practitioners Research and Surveillance Centre were analysed. A total of 231,545 individuals with a measurement of serum sodium concentration at baseline were included. Exclusion criteria were: age